Yes, you can create multiple sets with different conditions and different MailChimp settings.
Here is the example:
1. Pick one of set types:
2. Create new set, or pick your existing set, make sure you have configured lists, groups and fields.
3. In "Conditions" section select the product(s), that should be (or not) in cart for this set to be activated:
4. Repeat this for any other products and lists - you can create any amount of any combinations.